泛素
干扰素调节因子
细胞生物学
内生
转录因子
干扰素
生物
内部收益率1
免疫学
遗传学
基因
生物化学
作者
Rowan Higgs,Caroline A. Jefferies
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2008-05-21
卷期号:36 (3): 453-458
被引量:19
摘要
The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.
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