The Effect of Palmitoylethanolamide Analogue, N-(2-Morpholinoethyl) Palmitoylamide on Pain Behaviour in Mice

In the present study, we investigated the antinociceptive and anti-inflammatory properties of morpholino analogue of palmitoylethanolamide (PEA) by using abdominal constriction, formalin and tail flick tests. In the writhing test, the doses of 50 and 100 mg/kg of PEA analogue showed remarkable decrease in the number of abdominal constrictions when compared to diclofenac. The doses of 50 and 100 mg/kg of PEA analogue exhibited similar effect to morphine in formalin and tail flick tests. The results demonstrated that the PEA analogue exhibit central and peripheral antinociceptive activity in a dose-dependent manner. This presents a novel analgesic compound that may target the endogenous cannabinoid system for treatment of analgesic disorders.