新生内膜
医学
血管成形术
气球
动物模型
血栓形成
动物种类
再狭窄
药品
外科
心脏病学
药理学
内科学
支架
生物
动物
作者
Jamie Y. Jeremy,Anita C Thomas
出处
期刊:Current Vascular Pharmacology
[Bentham Science]
日期:2010-02-28
卷期号:8 (2): 198-219
被引量:19
标识
DOI:10.2174/157016110790887027
摘要
Neointima (NI) formation following arterial bypass graft surgery or balloon angioplasty is considered central to subsequent failure after these procedures. The NI promotes accelerated atherogenesis, re-occlusion and thrombosis resulting in a failure rate as high as 50% within 1-10 years. Furthermore, despite the relative success of statins and drug eluting stents, drugs that reduce the failure rate have as yet not been implemented. In turn, animal models are a crucial means of testing potential interventions, in particular, drugs. The objective of this review therefore is to provide a survey of all the possible models that can be used to explore the effects of drugs on NI formation. The review will focus on the most commonly used of species, namely the rat, rabbit, mouse, pig and dog.
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