A new multi-objective optimization design model of wheel profile was constructed,with three functions of the wheel/rail wear,the critical speed and the wheel/rail lateral force respectively as the objective functions,with the arc radius and the center coordinate of the arc-type wheel profile as the design variables,and with the engineering requirements which included Nadal derailment coefficient less than 1.0 described in code GB 5599—85,the maximum contact stress less than 3 times of the pure shear strength of the wheel materials and wheel rolling contact fatigue index less than 0 as the constraint conditions.ERRI 200 km·h-1 standard passenger car was chosen as an example and its dynamic model was constructed by means of railway vehicle dynamics simulation software ADAMS.2005/Rail.The multi-objective optimization design on LMa profile was implemented using the profile optimization model constructed in this paper.The optimal results show that the critical speed of vehicle equipped with optimal wheel profile increases 50% and the wheel/rail wear index reduces 12% at negotiating the curved track.