基因组
生物
DNA
DNA复制
遗传学
核苷酸
核苷酸
计算生物学
基因
作者
Jessica A. Williams,Thomas A. Kunkel
标识
DOI:10.1146/annurev-biochem-032620-110354
摘要
Our current view of how DNA-based genomes are efficiently and accurately replicated continues to evolve as new details emerge on the presence of ribonucleotides in DNA. Ribonucleotides are incorporated during eukaryotic DNA replication at rates that make them the most common noncanonical nucleotide placed into the nuclear genome, they are efficiently repaired, and their removal impacts genome integrity. This review focuses on three aspects of this subject: the incorporation of ribonucleotides into the eukaryotic nuclear genome during replication by B-family DNA replicases, how these ribonucleotides are removed, and the consequences of their presence or removal for genome stability and disease.
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