美托洛尔
阿替洛尔
药代动力学
医学
药理学
内科学
血压
作者
H Ledermann,H Bippi,Hilmar Boekens,Jürgen C. Frölich,H Herrmann,K Schmitt-Landherr
出处
期刊:PubMed
日期:1985-01-01
卷期号:35 (5): 848-51
被引量:5
摘要
18 healthy volunteers received conventional atenolol (Tenormin) 50 mg once daily and metoprolol 50 mg twice daily for 6 days in a balanced randomised cross-over fashion. There was a wash-out period of two weeks between each phase. Plasma concentrations of the drugs were measured on the last day of each phase. Comparison of the coefficients of variation showed a lower variability in the pharmacokinetics of atenolol compared to metoprolol. The clinical implications of these findings are discussed.
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