Gold‐Catalyzed Intramolecular Regio‐ and Enantioselective Cycloisomerization of 1,1‐Bis(indolyl)‐5‐alkynes

Bis(indole) alkaloids analogues were prepared under mild conditions and in high yields through a gold-catalyzed cycloisomerization of 1,1-bis(indolyl)-5-alkynes (see scheme). The enantioselective version of this reaction gave the corresponding products in moderate to excellent yields (55–90 %), moderate to good ee values (48–96 %), and satisfactory regioselectivities (3.5:1→20:1).