From spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis

Fibrosis is a pathological wound-healing response characterised by the excessive deposition of extracellular matrix components, ultimately disrupting the architecture and function of affected organs [1]. Idiopathic pulmonary fibrosis (IPF), the most severe form of idiopathic interstitial lung disease, exemplifies this process. IPF is a progressive and ultimately fatal disorder marked by irreversible remodelling of the lung parenchyma, leading to impaired gas exchange and respiratory failure [2].