颞叶
癫痫
睡眠纺锤
发作性
听力学
睡眠(系统调用)
心理学
脑电图
睡眠剥夺对认知功能的影响
认知
医学
慢波睡眠
神经科学
计算机科学
操作系统
作者
Alex C. Bender,Afareen Jaleel,Kyle R Pellerin,Sebastián Moguilner,Rani A. Sarkis,Sydney S. Cash,Alice Lam
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-12-05
卷期号:101 (23)
被引量:1
标识
DOI:10.1212/wnl.0000000000207942
摘要
Objectives:
To investigate the spatiotemporal characteristics of sleep waveforms in temporal lobe epilepsy (TLE) and examine their association with cognition. Methods:
In this retrospective, cross-sectional study, we examined overnight EEG data from adult patients with temporal lobe epilepsy (TLE) and non-epilepsy comparisons (NEC) admitted to the epilepsy monitoring unit (EMU) at Mass General Brigham hospitals. Automated algorithms were used to characterize sleep macro-architecture (sleep stages), and micro-architecture (spindles, slow oscillations) on scalp EEG, and to detect hippocampal interictal epileptiform discharges (hIEDs) from foramen ovale (FO) electrodes simultaneously recorded in a subset of TLE patients. We examined the association of sleep features and hIEDs with memory and executive function from clinical neuropsychological evaluations. Results:
A total of 81 TLE and 28 NEC adult patients were included with similar mean ages. There were no significant differences in sleep macro-architecture between groups, including relative time spent in each sleep stage, sleep efficiency, and sleep fragmentation. In contrast, the spatiotemporal characteristics of sleep micro-architecture were altered in TLE compared to NEC and were associated with cognitive impairments. Specifically, we observed a ∼30% reduction in spindle density in TLE compared to NEC patients, which was significantly associated with worse memory performance. Spindle-slow oscillation (SO) coupling strength was also reduced in TLE and, in contrast to spindles, was associated with diminished executive function. We found no significant association between sleep macro- and micro-architectural parameters and hIEDs. Conclusion:
There is a fundamental alteration of sleep micro-architecture in TLE, characterized by a reduction in spindle density and spindle-SO coupling, and these changes may contribute to neurocognitive comorbidity in this disorder.
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