白桦酸
氧化应激
雌激素受体
活性氧
超氧化物歧化酶
雌激素
生物
生殖毒性
药理学
丙二醛
内科学
内分泌学
化学
细胞生物学
毒性
医学
遗传学
癌症
乳腺癌
作者
Chenglin Yang,Yunqin Chen,Mengran Yang,Jiayan Li,You Wu,Hui Fan,Xiangyi Kong,Can Ning,Siqi Wang,Wenguang Xiao,Zhihang Yuan,Jine Yi,Jing Wu
标识
DOI:10.1016/j.envpol.2022.120435
摘要
Zearalenone (ZEA) is a mycotoxin with estrogen-like biological activity, which widely present in feed and raw materials, with strong reproductive system toxicity and a major threat to animal reproduction. Betulinic acid (BA) is a natural plant compound with antioxidant, anti-inflammatory and other pharmacological activities. However, the mechanism of ZEA-induced uterine injury and the protective effect of BA have not been reported. Our results show that ZEA could cause uterine histopathological damage and cellular ultrastructural damage, affecting the secretion of sex hormones, such as estradiol (E2) and progesterone (P4), and increase the mRNA and protein expression of estrogen receptor α (ERα). ZEA could inhibit the activities of catalase (CAT) and superoxide dismutase (SOD), increase the production of malondialdehyde (MDA) and reactive oxygen species (ROS), and cause uterine oxidative stress. Furthermore, ZEA affected the homeostasis of uterine cell proliferation and death by regulating the expression of proliferating cell nuclear antigen (PCNA) and activating the mitochondrial apoptotic pathway. ZEA-induced uterine injury might be related to the activation of p38/ERK MAPK signaling pathway. However, the regulatory effect of ZEA on the uterus was reversed after BA treatment. In conclusion, the uterus is an important target organ attacked by ZEA, and BA showed a good therapeutic effect.
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