Clinical observation of vinorelbine combined with capecitabine for treating advanced breast carcinoma

Objective To observe the clinical efficacy of chemotherapy using vinorelbine (NVB) combined with capecitabine in treatment of the patients with advanced breast cancer.Method For 34 patients,chemotherapeutic protocol was vinorelbine (25 mg/m 2 , d1,8) and capecitabine (2000 mg/m 2 ,bid,po,d1-14).Every 21 days constituted a cycle and the efficacy was evaluated using WHO standard after 2 cycles of treatment.Results The total response rate of thirty-four patients was 58.8%,with CR 4 cases,PR 16 cases,SD 12 cases and PD 2 cases.Toxic reactions included mild nausea,vomiting and leucopenia.Conclusion The chemotherapy with vinorelbine and capecitabine is an effective and safe method for the patients with advanced breast cancer.