ASSESSMENT OF CENTRAL AORTIC BLOOD PRESSURE IN PATIENTS WITH HYPERTENSION: RESULTS FROM A PAN-INDIA ASSESS CABP REGISTRY

Abstract Objective: Although central aortic blood pressure (CABP) has shown to be better predictor of cardiovascular events than brachial BP in randomized trials, the real-world clinical practice data are scarce. Our study aimed to assess brachial and CABP and illustrate the correlation between them in patients with hypertension. It also aimed to assess the therapeutic drug classes prescribed in hypertensive patients. Design and method: This was a single-visit, prospective, non-interventional, observational study of hypertensive outpatients. Data collection included clinical and demographic characteristics, brachial (sphygmomanometer) and CABP (Agedio B900 device (IEM, Stolberg, Germany) and antihypertensive treatment. Results: A total of 3989 patients were enrolled with the mean age of 56.6 ± 12.2 years. About 58.6% were male and 66.4% were obese. Mean systolic (SBP) and diastolic blood pressure (DBP) was 156 ± 15.2/ 95.6 ± 12.9 mm Hg. Mean arterial pressure was 119.4 ± 21.8 mm Hg and heart rate was 83.1 ± 14.6 bpm. The central blood pressure parameters were: central systolic blood pressure (CSBP), 139.8 ± 16.3 mm Hg; central diastolic blood pressure (CDBP), 96.1 ± 13.2 mm Hg; central pulse pressure (CPP), 43.4 ± 15.3 mm Hg; augmentation index (%), 29.1 ± 16.6; pulse wave velocity, 8.8 ± 3.8 m/s. A positive correlation was observed between SBP and CSBP (r = 0.6809, p < 0.0001); DBP and CDBP (r = 0.7413, p < 0.0001); and PP and CPP (r = 0.638, p < 0.0001). About 83.1% patients were taking antihypertensive medications and 76.94% (n = 3163) patients were receiving monotherapy: ACE inhibitors, 6.96%, angiotensin receptor blockers, 30.92%, beta-Blockers, 12.6%, calcium channel blockers, 17.93%, diuretics, 8.54%, and alpha/central blockers, 0.17%. Combinations of two and three drugs were received by 21.6% and 1.46%, respectively Conclusions: Brachial BP was positively correlated to CABP in hypertensive patients. Majority of patients were receiving angiotensin receptor blockers as antihypertensive monotherapy.