Metal organic frameworks as advanced functional materials for aptasensor design

Advancement in coordination chemistry has achieved an impressive development of metal organic frameworks (MOFs) as the supramolecular hybrid materials, comprising harmonized metal nodes with organic ligands. Scope and approach: MOFs offer the unique properties of easy synthesis, nanoscale structure, adjustable size and morphology, high porosity, large surface area, supreme chemical tunability and stability, and biocompatibility. The features provide an exceptional opportunity for the widely usage of MOFs in the different scientific fields, e.g. biomedicine, electrocatalysis, food safety, energy storage, environmental surveillance, and biosensing platforms. The synergistic incorporation of the aptamer advantages and the superiorities of MOFs attains the novel MOF-based aptasensors. The excellent selectivity and sensitivity of the MOF-based aptasensors nominate them as efficient lab-on-chip tools for cost-effective, label-free, portable, and real-time monitoring of diverse targets.Here, we review the achievements in the sensor design by cooperation of MOF motifs and aptamers with the conspicuous potential of determining the targets. Finally, some results are expressed that provide a valuable viewpoint for developing the novel MOF-based test strips in the future.