Objective To explore the effect of prescription evaluation system on rational drug use.Methods A total of 825 prescriptions written for medications in Shenzhen Bao'an District Fuyong People's Hospital between 2012-2013 were selected as the research subjects and were divided into two groups. The prescription evaluation system was used in intervention group,but not in non-intervention group. The basic prescription indexes and the proportion of irrational prescriptions were compared between the two groups. Results Compared with non-intervention group,the basic prescription indexes were significantly improved in intervention group( P 0. 05). In addition, the proportions of non-standard prescriptions,inappropriate medication prescriptions and unconventional prescriptions in intervention group were significantly lower than those in non-intervention group(P0.05). Conclusion Prescription evaluation system can significantly increase the proportion of rational prescriptions and reduce unreaso-nable prescription-induced adverse reactions and medical costs.Therefore,prescription evaluation system has an important clinical value.