Effects of Baicalin on the Chronic Alcoholic Liver Injury in Rat

Objective:To observe the effects of baicalin in chronic alcoholic live injury rats,and to study the terapeutic effects and mechanisms of baicalin on alcoholic live injury rats. Methods:The rats were given 56°(v/v) alcohol 5 mL·kg~ -1 twice daily for 28 days by ig,from the 5~ th week once daily for 4 weeks.In the same time the rats were given test agents according to the protocol for 28 days. Results: The experiments indicated that baicalin could obviously degraded the content of ALT,AST,MDA in rats'serum and liver and increased the activity of SOD and GSH-Px. It also reduced the content of TNF-α in serum. Conclusions: Baicalin has obvious protective effect to alcoholic liver injury in rats. Down regulation of TNF-α and MDA might be involved in the mechanism.