Letters to the Editor 57 cell expressed FLI-1 and CD31; but were negative for S100-antigen, CD34, CD45, SOX10, CK AE1/AE3, EMA, and desmin.Therefore, the patient was a candidate for radiation therapy.Cardiac tumors are rare.Patient appropriate treatment for cardiac tumor depends on histological diagnosis and staging.Non-surgical cardiac mass biopsy evaluation can be done by transvascular (artery and vein) and percutaneous approach.Right cardiac biopsies are commonly performed through the venous access.Left cardiac biopsies are most commonly performed through the arterial access.Not all patients with left atrium lesions can undergo diagnostic and therapeutic surgeries.Percutaneous CT guided cardiac biopsy procedures date back to the early 2000s (2, 3) particularly for the left atrial masses.Percutaneous thoracic imaging guided approach can be indicated in selected cases, with previous multidisciplinary discussions paying attention on the mass anatomical location, characteristics, and extension (1-4).In general, percutaneous transthoracic biopsy procedures may be useful in those cases where traditional approaches or methods have resulted in a possible technical failure or are too complicated.In conclusion, cardiac masses located in the posterior wall of the left atrium can be one of the cases where percutaneous imaging guided biopsy is indicated.