对映选择合成
立体中心
钴
催化作用
产量(工程)
化学
环戊二烯基络合物
表面改性
组合化学
立体化学
有机化学
材料科学
物理化学
冶金
作者
Qi‐Jun Yao,Jiahao Chen,Hong Song,Fan‐Rui Huang,Bing‐Feng Shi
标识
DOI:10.1002/anie.202202892
摘要
Previous methods on CoIII -catalyzed asymmetric C-H activation rely on the use of tailor-made cyclopentadienyl-ligated CoIII complexes, which require lengthy steps for the preparation. Herein, we report an unprecedented enantioselective C-H functionalization enabled by a simple cobalt/salicyloxazoline (Salox) catalysis. The chiral Salox ligands can be easily prepared in one step from salicylonitrile and chiral amino alcohols. A broad range of P-stereogenic compounds were synthesized in high yields with excellent enantioselectivities (45 examples, up to 99 % yield and >99 % ee). The isolation and characterization of several intermediates provided insights into the generation of active catalytic cobalt species, the action of Salox, and the mode of stereocontrol.
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