荧光
极性(国际关系)
癌细胞
生物物理学
膜
化学
量子产额
荧光寿命成像显微镜
细胞膜
斯托克斯位移
细胞毒性
细胞
生物化学
生物
癌症
体外
光学
物理
遗传学
作者
Lixian Fu,Yiyun Tan,Yue Ding,Weixia Qing,Y Wang
标识
DOI:10.1016/j.cclet.2023.108886
摘要
A novel D-π-A structure and near-infrared fluorescent probe (DCITT) with high polarity sensitivity and membrane targeting was reported. The fluorescent spectra of DCITT were polarity dependent and Stokes shift was greater than 300 nm. Due to its high fluorescence quantum yield, low cytotoxicity and photostability, DCITT could be used as a labeling probe in multicellular organisms. In particular, DCITT effectively distinguished tumorous cells from normal cells because it could specifically light up the cancer cells membrane based on strong red fluorescence for a long time. On this basis, a polar-sensitive cell membrane probe is developed to differentiate tumorous cells from normal cells, which provides an idea and method for the early diagnosis of tumor at cellular level.
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