内生
有机体
甲醛
药理学
对偶(语法数字)
毒理
化学
生物
生物化学
哲学
遗传学
语言学
作者
Jiaxin Chen,Wenhui Chen,Jinjia Zhang,Hui Zhao,Ji Cui,Junzi Wu,Anhua Shi
摘要
Abstract Endogenous formaldehyde (FA) is produced in the human body via various mechanisms to preserve healthy energy metabolism and safeguard the organism. However, endogenous FA can have several negative effects on the body through epigenetic alterations, including cancer growth promotion; neuronal, hippocampal and endothelial damages; atherosclerosis acceleration; haemopoietic stem cell destruction and haemopoietic cell production reduction. Certain medications with antioxidant effects, such as glutathione, vitamin E, resveratrol, alpha lipoic acid and polyphenols, lessen the detrimental effects of endogenous FA by reducing oxidative stress, directly scavenging endogenous FA or promoting its degradation. This study offers fresh perspectives for managing illnesses associated with endogenous FA exposure.
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