Structure modification of mangiferin

OBJECTIVE In order to look for new antidiabetic compounds,the structure of mangiferin is modified.METHODS Using mangiferin as starting material,a series of 3,6,7-O-trisubstituted derivatives of mangiferin were synthesized,and then their antidiabetic activities were tested in vitro with mangiferin as the control.RESULTS A total of 11 target compounds were synthesized,and their structures were all confirmed by 1HNMR.CONCLUSION Compounds 5 and 11 were shown to have better antidiabetic activities than mangiferin.