适体
微泡
化学
纳米技术
机制(生物学)
癌症研究
小RNA
癌症治疗
癌症
计算生物学
生物物理学
生物化学
分子生物学
认识论
内科学
基因
哲学
生物
医学
材料科学
作者
Jianmei Zou,Muling Shi,Xiaojing Liu,Jinghui Cheng,Xiaojing Xing,Liping Qiu,Weihong Tan
标识
DOI:10.1021/acs.analchem.8b05204
摘要
Exosomes (Exos) are nanoscale natural vehicles for transporting biomolecules to facilitate cell-to-cell communication, indicating a high potential of them for delivering therapeutics/diagnostics. To improve their delivery capacity, a simple, noninvasive, and efficient strategy for functionalizing Exos with effective targeting ligands as well as elucidation of the cellular uptake mechanism of these functionalized Exos was found be to necessary, but remained a challenge. In this work, we used diacyllipid-aptamer conjugates as the targeting ligand to develop an aptamer-functionalized Exos (Apt-Exos) nanoplatform for cell type-specific delivery of molecular therapeutics. The cellular uptake mechanism of Apt-Exos was investigated in details, and distinct behavior was observed in comparison to free Exos. By combining the excellent molecular recognition capability of aptamers and the superiority of Exos as natural vehicles, Apt-Exos can efficiently deliver molecular drugs/fluorophores to target cancer cells, providing a promising delivery platform for cancer theranostics.
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