Assessing Chemical Migration from Plastic Food Packaging into Food Simulant by Gas and Liquid Chromatography with High-Resolution Mass Spectrometry

Some components of plastic food packaging can migrate into food, and whereas migration studies of known components are required and relatively straightforward, identification of nonintentionally added substances (NIAS; unknowns) is challenging yet imperative to better characterizing food safety. To this aim, migration was investigated across 24 unique plastic food packaging products including plastic wrap, storage bags, vacuum bags, and meat trays. Gas and liquid chromatography separation systems coupled with Orbitrap mass analyzers were used for comprehensive nontargeted screening of migrants. Tentative identifications of features were assigned by searching commercial databases (e.g., NIST, MZCloud, ChemSpider, Extractables and Leachables) and filtering results based on mass accuracy, retention time indices, and mass spectral patterns. Several migrants showed elevated levels in specific food packaging types, particularly meat trays and plastic wrap, and varying degrees of migration over the 10 days. Eleven putative migrants are listed as substances of potential concern or priority hazardous substances. Additionally, migration amounts of an Irgafos 168 degradation product determined by semiquantitation exceeded proposed theoretical maximum migration values.