过度活跃
乙型肝炎表面抗原
血清转化
免疫学
乙型肝炎
乙型肝炎病毒
免疫系统
医学
CD80
B细胞
病毒学
CD40
内科学
抗体
生物
病毒
体外
细胞毒性T细胞
生物化学
作者
Xiangsheng Xu,Qinghua Shang,Xinyue Chen,Weimin Nie,Zhengsheng Zou,Ang Huang,Meng Mao,Lei Jin,Ruonan Xu,Jiyuan Zhang,Junliang Fu,Lifeng Wang,Zuoyin Tang,Yunbo Xie,Xiaoming Yang,Zheng Zhang,Fusheng Wang
摘要
B cells play an important role in the clearance of hepatitis B virus (HBV) and protection against reinfection. However, the functional characteristics of these cells that are associated with the outcome of chronic HBV infection remain unknown. We comprehensively investigated the frequency, phenotype, and function of peripheral B-cell subsets from CHB patients in different phases: immune tolerance (IT), immune activation (IA), immune clearance (IC), responders with HBsAg seroconversion (resolved patients, RP), and healthy controls (HC). IA patients displayed lower percentages of peripheral blood memory B cells compared with the other groups. Overall polyclonal activation of B cells, indicated by higher levels of activation markers and secretion of IgG and IgM, was observed in IA patients. This B-cell hyperactivation could be induced by increased IFN-α and soluble CD40 ligands in IA patients. Notably, the expression of the co-stimulator molecule CD80 and serum HBsAb and the frequency of HBsAg-specific B cells were significantly decreased in IT, IA, and IC patients compared with HC subjects. More importantly, the B-cell hyperactivation, co-stimulatory molecule downregulation and HBsAg-specific B-cell impairment were reversed in RP patients. The reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients.
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