肾
免疫学
发病机制
CD8型
细胞毒性T细胞
T细胞
生物
胃肠道
肾脏疾病
疾病
T细胞受体
医学
免疫系统
病理
内科学
内分泌学
体外
生物化学
作者
Andrea M Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
标识
DOI:10.1016/j.kint.2022.02.035
摘要
Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell-directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
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