We introduce wearable chemical sensors based on flexible surface-enhanced Raman spectroscopy (SERS) substrates. These wearable SERS sensors, composed of gold- or silver-coated polyvinyl alcohol nanomesh, facilitate non-invasive, on-site detection of the wearer's biofluids through highly sensitive, label-free, multiplexed chemical analysis. In this talk, a recent breakthrough in this field, namely the development of highly scalable SERS sensors is presented. The excellent performance of the sensors, namely, high sensitivity, flexibility, stretchability, durability, reproducibility, uniformity, and wearability, are discussed. Furthermore, we show their diverse applications ranging from food safety testing to health monitoring.