Single-cell transcriptomics reveal potent extrafollicular B cell response linked with granzyme K+CD8 T cell activation in lupus kidney

B and T cells constitute the majority of infiltrating lymphocytes in the kidney and represent the local perpetrators in lupus nephritis (LN), but the underlying pathogenic mechanisms are not well elucidated. The aim of this study is to explore the kidney-specific adaptive immune landscape in patients with active LN at the single-cell level.