Treatment Pattern, Healthcare Resource Utilization and Symptom Burden Among Patients with Triple Class Exposed Multiple Myeloma: A Population-Based Cohort Study

多发性骨髓瘤 队列 医学 医疗保健 人口 肿瘤科 环境卫生 内科学 经济增长 经济
作者
Hira Mian,Hsien Seow,Gregory R. Pond,Anastasia Gayowsky,Ronan Foley,Amaris Balistky,Mohammed Ebraheem,Christopher Cipkar,Hyra Sapru,Ghulam Rehman Mohyuddin,Samer Al Hadidi,Alissa Visram
出处
期刊:Clinical Lymphoma, Myeloma & Leukemia [Elsevier BV]
卷期号:24 (6): e227-e234
标识
DOI:10.1016/j.clml.2024.02.006
摘要

Abstract

Purpose

This study aims to describe the treatment patterns, outcomes, health care utilization and symptom burden of triple class exposed (TCE) relapsed/refractory patents with multiple myeloma (MM) receiving a subsequent line of treatment (LOT).

Methods

This is a retrospective observational cohort study using administrative databases in Ontario, Canada. Outcomes were captured for TCE patients receiving a subsequent LOT and included: treatment regimen details, time to next treatment (TTNT), overall survival (OS), health care utilization, palliative care referral, and patient reported symptoms.

Results

Of the 16,777 patients diagnosed with MM between 2007-2021 in Ontario, 1358 (8%) patients were classified as TCE. Among the TCE MM patients, 489 (36%) received a subsequent LOT. The two most commonly administered therapies post TCE were carfilzomib/dexamethasone (n = 111, 22%) and pomalidomide/dexamethasone(n = 95, 19%). Median TTNT was 1.7 months (95%CI 1.2-2.4 months) and median OS 12.8 months (95%CI 10.8-16.5). Healthcare utilization was high with 276 (56%) of patients evaluated in an emergency department (ED) or admitted to hospital. There was high symptom burden as reported by patients with moderate-severe impairment in well-being, fatigue, pain and drowsiness noted in greater than 25% of the cohort. Palliative care referrals rates were low with only 10% (n = 48) patients referred to palliative care. Among the patients that died during study follow up, the majority died in hospital (n = 147,44%).

Conclusion

Our study reports one of the largest series of real-world TCE patients published and demonstrates the poor outcomes of TCE patients receiving a subsequent LOT.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小乐举报尹冰之求助涉嫌违规
刚刚
蔡蔡不菜菜发布了新的文献求助100
1秒前
1秒前
李健的小迷弟应助YY采纳,获得10
1秒前
Amon完成签到,获得积分10
1秒前
张道恒发布了新的文献求助10
1秒前
可爱的函函应助hanjresearch采纳,获得10
1秒前
小鬼完成签到,获得积分10
2秒前
科研通AI6应助知行合一采纳,获得30
2秒前
帅气白梦发布了新的文献求助10
2秒前
涵泽发布了新的文献求助10
3秒前
月落无痕97完成签到 ,获得积分10
3秒前
倒立才能看文献完成签到,获得积分10
3秒前
Faith发布了新的文献求助10
4秒前
4秒前
mly完成签到 ,获得积分10
4秒前
xc发布了新的文献求助10
4秒前
小马甲应助山月采纳,获得10
5秒前
小蘑菇应助棵虫采纳,获得10
5秒前
6秒前
erdongsir发布了新的文献求助10
6秒前
天真发布了新的文献求助10
6秒前
6秒前
7秒前
7秒前
Elokuu_完成签到,获得积分10
7秒前
sun完成签到,获得积分10
7秒前
lin发布了新的文献求助10
8秒前
8秒前
8秒前
8秒前
8秒前
像风一样完成签到,获得积分10
8秒前
9秒前
张道恒完成签到,获得积分10
9秒前
小徐爱絮叨完成签到,获得积分20
10秒前
64658应助是小曹啊采纳,获得10
10秒前
文艺千柳应助Mine采纳,获得10
10秒前
栗子完成签到 ,获得积分10
10秒前
韩霖发布了新的文献求助10
11秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Разработка технологических основ обеспечения качества сборки высокоточных узлов газотурбинных двигателей,2000 1000
Optimization and Learning via Stochastic Gradient Search 500
Nuclear Fuel Behaviour under RIA Conditions 500
Why America Can't Retrench (And How it Might) 400
Higher taxa of Basidiomycetes 300
Ricci Solitons in Dimensions 4 and Higher 240
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 物理化学 基因 催化作用 遗传学 冶金 电极 光电子学
热门帖子
关注 科研通微信公众号,转发送积分 4688750
求助须知:如何正确求助?哪些是违规求助? 4061435
关于积分的说明 12557156
捐赠科研通 3758855
什么是DOI,文献DOI怎么找? 2075942
邀请新用户注册赠送积分活动 1104622
科研通“疑难数据库(出版商)”最低求助积分说明 983700