Novel Isoindolin-1-one Derivatives as Metabotropic Glutamate Receptor Positive Allosteric Modulators

This highlight outlines the development of novel substituted isoindolin-1-one derivatives as potential positive allosteric modulators (PAMs) for group II metabotropic glutamate receptors (mGluR2/mGluR3). The disclosure includes details on synthetic methods, biological evaluation, and pharmaceutical compositions.