Graphene Oxide/CuO/ZnO Nanocomposite Combined Carbon Fibers as a Sensor for the Determination of Antibiotic Chloramphenicol

A nano-composition of graphene oxide (GO), copper oxide (CuO), and zinc oxide (ZnO) was synthesized by utilizing the co-precipitation method and characterized by various methods. The synthesized GO/CuO/ZnO nanocomposite was utilized as a modifier combined with carbon fiber (CF) on the glassy carbon electrode (GO/CuO/ZnO@CF/GCE). The modified electrode was utilized to determine the antibiotic chloramphenicol (CAP), which risks public and environmental health by arising as residue, especially in food samples. Cyclic voltammetry and differential voltammetric techniques were used to investigate the electrochemical performance of CAP on the GO/CuO/ZnO@CF/GCE, and it established excellent electrocatalytic activity compared to bare glassy carbon electrode (BGCE). The electroactive surface area of BGCE and GO/CuO/ZnO@CF/GCE were found to be 0.03605 cm 2 and 0.05215 cm 2 respectively. Scan-rate studies reveal the diffusion-controlled electrode process at GO/CuO/ZnO@CF/GCE. The modified electrode showed a high sensitivity of 1.45 μA μM −1 cm −2 with a low detection limit (13.3 μM). The prepared modified electrochemical sensor had well repeatability and reproducibility, adequate stability, and good selectivity toward the determination of CAP. Moreover, prepared (GO/CuO/ZnO@CF/GCE) was utilized to measure CAP in real samples such as milk and honey.