The role of the hippocampus in the consolidation of emotional memories during sleep

Abstract

Episodic memory relies on the hippocampus, a heterogeneous brain region with distinct functions. Spatial representations in the dorsal hippocampus (dHPC) are crucial for contextual memory, while the ventral hippocampus (vHPC) is more involved in emotional processing. Here, we review the literature in rodents highlighting the anatomical and functional properties of the hippocampus along its dorsoventral axis that underlie its role in contextual and emotional memory encoding, consolidation, and retrieval. We propose that the coordination between the dorsal and vHPC through theta oscillations during rapid eye movement (REM) sleep, and through sharp-wave ripples during non-REM (NREM) sleep, might facilitate the transfer of contextual information for integration with valence-related processing in other structures of the network. Further investigation into the physiology of the vHPC and its connections with other brain areas is needed to deepen the current understanding of emotional memory consolidation during sleep.