Determination of camphor,borneolum and menthol syntheticum in Touguling adhesive plasters by GC

OBJECTIVE To establish method for determination of camphor,borneol and menthol in Touguling adhesive plasters by capillary GC.METHODS Naphthalene was employed as the intrenal standard,and added to the sample before treatment.The sample solution was prepared by distillation with essential oil collector.The GC system,with HP-5 capillary column as the stationary phase,nitrogen as the carrier gas,temperature programmed method was used,and FID was used as the detector.RESULTS Camphor,synthetic borneol(borneol and isoborneol),menthol,and methyl salicylate in 6 lots of samples and naphthalene were separated well under the chromatographic condition.In the methodological study on Touguling adhesive plasters,the average recovery of camphor,menthol,synthetic borneol were 98.2%(RSD=0.42%),102.4%(RSD=1.08%) and 101.0%(RSD=2.34%),respectively.CONCLUSION The method is sensitive,accurate and reproducible,and can be used to control the quality of the four kinds of preparations.