Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm

Key Points Loss of Ezh2 inhibits erythropoiesis but increases megakaryopoiesis in Jak2V617F knock-in mice. Loss of Ezh2 induces rapid progression to myelofibrosis in mice expressing Jak2V617F.