PEG-coated magnesium peroxide nanosheets with tunable microstructure: Effect of microstructure on concurrent oxygen and magnesium ion release

Delivering adequate oxygen to improve cell survival in a tissue-engineered scaffold is one of the most critical matters by using oxygen-generating biomaterials (OGBs). Magnesium peroxide is one of the OGBs with the ability to release dual magnesium ions and oxygen within liquid environments. In this study, polyethylene glycol coated Magnesium peroxide nanosheets (PEG-MPOSs) with different microstructures were synthesized by the coprecipitation method, and the effect of reagents mixing rate was studied. The results showed diameter of nanosheets and lattice strain were increased by increasing reagents mixing rate, while crystalline sizes were decreased. Moreover, it was found that the amount of magnesium and oxygen released from PEG-MPOSs in 24 days can be tuned by controlling the microstructure, and the fabricated PEG-MPOSs can be used in tissue engineering applications.