Cross-organ single-cell integration identifies liver-specific fibroblast programs and HGF-MET/AGT-AGTR1B axes that link fibrosis to hepatocarcinogenesis.

Cross-organ single-cell integration prioritizes liver-selective stromal circuitry and nominates hepatocyte-FB axes (HGF-MET, AGT-AGTR1B) as plausible links between fibrogenic remodeling and a pro-tumorigenic niche, yielding testable hypotheses at the interface of regeneration, RAS biology, and tumor initiation.