Comparative analysis of fibrinolytic therapy effect of urokinase and reteplase at enzyme in the treatment of acute myocardial infarction

Objective To study and analyze the fibrinolytic therapy effect of urokinase and reteplase in the treatment of acute myocardial infarction(AMI). Methods The clinical data of 78 cases of patients with acute myocardial infarction(AMI) who had been treated in our hospital from March 2011 to April 2013 were retrospectively analyzed, they were divided into control group and treatment group on the average, the control group were given urokinase, and the treatment group were given reteplase treatment, then the blood vessels in the pass rate, mortality and complications, and so on of the two groups of patients were comparatively analyzed. Results The vascular rate of the control group and treatment group of patients were 53.8%, 94.9% respectively; And the mortality rates were 7.7%, 0%; the bleeding complications rate were 30.8%, 17.9% respectively, the recanalization time of the treatment group was early, the recanalization rate was higher than those of the control group, the differences of the two groups were statistically significant(P0.05). The vascular rate of thrombolysis after 60 mins of the treatment group patients was 64.1%, the blood vessels of thrombolysis after 90 mins was 94.9%, and the blood vessel of thrombolysis after 120 mins was 97.4%, the differences of the treatment group and control group were significant(P0.05). Conclusion Reteplase has earlier coronary artery recanalization time, higher coronary artery recanalization rate, longer drug maintenance time and less adverse reaction in the treatment of acute myocardial infarction, it is a kind of efficient, safe clinical thrombolytic drugs, so is worthy of popularization and application.