Remission maintenance in acute lymphocytic leukemia with hydroxyurea.

Summary After complete remission had been induced by prednisone and vincristine in children with acute leukemia, hydroxyurea was used in an effort to maintain remission. No significant prolongation of remission occurred despite the appearance of toxicity in over 50% of the high dosage group. An equally significant observation was that the duration of remission produced by prednisone and vincristine was longer in those who had not received vincristine during a prior induced remission.