膜
化学
两亲性
吡啶
生物物理学
吡咯
荧光
细胞膜
量子产额
脂质双层
光化学
分子
有机化学
生物化学
共聚物
聚合物
物理
生物
量子力学
作者
Ziting Li,Shisheng Cui,Jiayu Yu,Jiamin Qu,Jianbing Shi,Bin Tong,Zhengxu Cai,Yu-Ping Dong
标识
DOI:10.1002/cnma.202200156
摘要
Abstract The cell membrane protects the cell stability and balance and participates in various physiological activities as an exchange channel. Therefore, the real‐time monitoring of cell membrane biological dynamics can help us understand the physiological state of the current cell. Herein, a type of amphiphilic near infrared (NIR) aggregation‐induced emission (AIE) molecules was designed and synthesized. Multiarylpyrroles (MAPs) with a dodecyl chain at the 1‐position of the pyrrole ring, charged pyridinium sulfonate at the 2,5‐position of the pyrrole ring and free rotating aryls at the 3‐position of the pyrrole ring can target cell membranes. One of the MAPs, MAP22 , had a maximum emission wavelength in the aggregation state of up to 721 nm with a large Stokes shift (∼280 nm). In addition, MAP22 nanoparticles can produce reactive oxygen species (ROS) with a quantum yield of 224%. Therefore, these AIE MAPs are promising candidates for theranostic nanoagents, including NIR fluorescence imaging to target cell membranes and ablate cancer cells by producing ROS.
科研通智能强力驱动
Strongly Powered by AbleSci AI