Fingernail-based metabolomics reveals a stepwise decline in dodecanoic acid associated with Alzheimer’s disease progression

Dodecanoic Acid emerges as a key biomarker reflecting disrupted fatty acid metabolism during AD progression. By enabling long-term metabolic profiling, fingernail metabolomics presents a promising, scalable, and non-invasive strategy for early diagnosis, staging, and monitoring of neurodegenerative diseases.