免疫系统
趋化因子
免疫学
先天性淋巴细胞
生物
白细胞介素21
细胞生物学
白细胞介素12
Janus激酶3
自然杀伤细胞
先天免疫系统
T细胞
细胞毒性
细胞毒性T细胞
体外
生物化学
作者
Cai Zhang,Zhigang Tian
标识
DOI:10.1016/j.jaut.2017.02.005
摘要
Natural killer (NK) cells are lymphocytes of the innate immune system. They not only exert cell-mediated cytotoxicity against tumor cells or infected cells, but also play regulatory role through promoting or suppressing functions of other immune cells by secretion of cytokines and chemokines. However, overactivation or dysfunction of NK cells may be associated with pathogenesis of some diseases. NK cells are found to act as a two edged weapon and play opposite roles with both regulatory and inducer activity in autoimmune diseases. Though the precise mechanisms for the opposite effects of NK cells has not been fully elucidated, the importance of NK cells in autoimmune diseases might be associated with different NK cell subsets, different tissue microenvironment and different stages of corresponding diseases. The local tissue microenvironment, unique cellular interactions and different stages of corresponding diseases shape the properties and function of NK cells. In this review, we focus on recent research on the features and function of different NK cell subsets, particularly tissue-resident NK cells in different tissues, and their potential role in autoimmune diseases.
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