薗头偶联反应
化学
酰胺
钌
组合化学
催化作用
基质(水族馆)
小学(天文学)
级联反应
药物化学
立体化学
钯
有机化学
海洋学
物理
地质学
天文
作者
Akanksha Singh Baghel,Amit Kumar
摘要
Herein, we report ruthenium(II)-catalyzed weakly coordinating primary amide-assisted ortho-di-alkynylation of (hetero)arylamides via double C-H bond activation in the presence of bromo-alkynes as coupling partners. The attractive features of the developed strategy lie in the usage of an inexpensive ruthenium(II)-salt, external auxiliary-free directing group and simple reaction conditions, along with a broad substrate scope, high reaction yields and scale-up synthesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI