富血小板血浆
医学
数据提取
梅德林
标准化
临床试验
重症监护医学
医学物理学
药理学
血小板
计算机科学
内科学
化学
生物化学
操作系统
作者
Daniela Vianna Pachito,Ângela Maria Bagattini,Arací Malagodi de Almeida,Alfredo Mendrone‐Júnior,Rachel Riera
标识
DOI:10.3389/fcell.2020.598816
摘要
Introduction Platelet-rich plasma is widely used for different types of clinical situations, but universal standardization of procedures for its preparation is still lacking. Methods Scoping review of comparative studies that have assessed at least two alternatives in one or more stages of preparation, storage and/or administration of PRP or its related products. A systematic search was conducted in MEDLINE, Embase, and LILACS. Two authors screened references independently. Data extraction was performed iteratively, and results were presented for each included comparison. Results Thirty-nine studies were included after assessing full texts, focusing on the comparison of PRP to a related product, types of anticoagulants, centrifugation protocols, commercial kits, processing time, methods for activation, and application concomitantly to other substances. Only laboratory outcomes were assessed, as platelet, leukocyte and growth factor concentrations. Conclusion Results showed great variability related to methods employed in different stages of PRP processing, which may explain the variability observed in clinical trials assessing the efficacy of PRP for different clinical situations.
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