Anti-tumor alkaloids from Peganum harmala

Six alkaloids peharmalines F-K, along with 14 known ones, were isolated from the aerial part of Peganum harmala L.. The structures of the isolated compounds were determined based on their HR-ESI-MS data, extensive NMR spectroscopic analyses, and ECD calculations. 3-(4-Hydroxyphenyl)quinoline exhibited potent antiproliferative activity against the HepG-2 cell lines with an IC50 value of 3.05 μM. Norharmane displayed a moderate inhibition against A549 and HepG-2 cells with IC50 values of 16.45 μM and 17.27 μM, respectively.