Deciphering the spatial tumor microenvironment in intrahepatic cholangiocarcinoma

1Laboratory of Experimental Hepatology and Drug Targeting (HEVEPHARM), University of Salamanca, National Institute for the Study of Liver and Gastrointestinal Diseases (CIBEREHD), IBSAL, Salamanca, Spain 2Institute of Pathology, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany 3Department of Surgery, Erasmus MC Transplantation Institute, University Medical Center Rotterdam, Rotterdam, Netherlands Abbreviations: CAF, cancer associated fibroblast; CK, cytokeratin; FFPE, formalin-fixed paraffin-embedded; HAIC, hepatic arterial infusion chemotherapy; HBV; hepatitis B virus; iCCA, intrahepatic cholangiocarcinoma; ICIs, immune checkpoint inhibitors; TLS, tertiary lymphoid structures; TME, tumor microenvironment. Correspondence Rocio I.R. Macias, Campus M. Unamuno, Edificio Departamental, Lab. B-17 University of Salamanca, 37007, Salamanca, Spain. Email: [email protected]