促炎细胞因子
肠道菌群
肠-脑轴
植物乳杆菌
下调和上调
超氧化物歧化酶
脑源性神经营养因子
丙二醛
生物
神经营养因子
氧化应激
内分泌学
免疫学
化学
内科学
生物化学
医学
炎症
受体
遗传学
乳酸
基因
细菌
作者
Hui Nie,Xinxin Wang,Yanghe Luo,Fanyu Kong,Guangqing Mu,Hui Nie
标识
DOI:10.1021/acs.jafc.3c09675
摘要
Gut microbiota can influence cognitive ability via the gut–brain axis. Lactiplantibacillus plantarum MWFLp-182 (L. plantarum MWFLp-182) was obtained from feces of long-living individuals and could exert marked antioxidant ability. Interestingly, this strain reduced the D-galactose-induced impaired cognitive ability in BALB/c mice. To comprehensively elucidate the underlying mechanism, we evaluated the colonization, antioxidant, and anti-inflammatory activities of L. plantarum MWFLp-182, along with the expression of potential genes associated with cognitive ability influenced and gut microbiota. L. plantarum MWFLp-182 enhanced the expression of anti-inflammatory cytokines, reduced the expression of proinflammatory cytokines, and increased tight junction protein expression in the colon. Moreover, L. plantarum MWFLp-182 could modify the gut microbiota. Notably, treatment with L. plantarum MWFLp-182 upregulated the expression of postsynaptic density protein-95, nuclear factor erythroid 2-related factor, nerve growth factor, superoxide dismutase, and brain-derived neurotrophic factor/neuronal nuclei, while downregulating the expression of bcl-2-associated X and malondialdehyde in the hippocampus and upregulating short-chain fatty acids against D-galactose-induced mouse brain deficits. Accordingly, L. plantarum MWFLp-182 could improve cognitive ability in a D-galactose-inducing mouse model.
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