窦房结
变时性
二氢吡啶
敌手
内分泌学
内科学
去极化
化学
豚鼠
舒张去极化
膜电位
钙
生物物理学
受体
生物
生物化学
医学
心率
血压
作者
Haruko Masumiya,Yoshio Tanaka,Hikaru Tanaka,Koki Shigenobu
出处
期刊:Pharmacology
[S. Karger AG]
日期:2000-01-01
卷期号:61 (2): 57-61
被引量:16
摘要
The effects of aranidipine, a novel dihydropyridine Ca(2+) channel antagonist, on membrane currents in guinea pig ventricular myocytes and on action potentials in rabbit sinoatrial node tissue were examined. In myocytes, aranidipine (10 nmol/l to 1 micromol/l) concentration-dependently decreased T-type and L-type Ca(2+) currents. Aranidipine (1 micromol/l) had little effect on K(+) currents. In the sinoatrial node, 0.1 micromol/l aranidipine increased cycle length, and decreased +V(max) and the slope of the phase 4 depolarization. Thus, inhibition of both T-type and L-type Ca(2+) currents by aranidipine may partly explain its potent negative chronotropic activity.
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