Prevalence, Etiology and Outcomes of Native Pulmonary Regurgitation in the General Adult Population

Abstract Aims Pulmonary regurgitation (PR) after reparative intervention for congenital heart disease has been studied extensively. However, the burden, distribution of causes, and outcome of PR in adults is unknown. The study aimed to evaluate the prevalence, types, and outcomes of moderate/severe PR in adults in the community setting. Methods and Results A total of 398 adult residents of Olmsted County who had clinically indicated echocardiography 2004-2023 at Mayo Clinic, Rochester and had moderate or severe PR were identified retrospectively. Median age was 77 years, 48% were females, and 61 (51%) had severe PR. The age and sex-adjusted U.S. prevalence was 0.11% (vs 0.67% for ≥moderate tricuspid regurgitation). Moderate/severe PR was due to pulmonary hypertension in 77%, congenital/iatrogenic in 11%, primary pulmonary valve disease in 2% (88% due to carcinoid), and idiopathic isolated in 10%. In contrast, severe PR was due to congenital/iatrogenic disease in 52%, pulmonary hypertension in 39%, primary PR in 5% and isolated idiopathic in 3%. All-cause mortality rate per 100-person-year was 73 in primary (mostly carcinoid) PR, 16 in pulmonary hypertension-related PR (not different vs propensity matched patients without PR), and 6 in isolated idiopathic PR (not different vs matched patients without PR). Conclusions Moderate or severe PR had a lower prevalence vs TR. The most frequent cause was pulmonary hypertension for ≥moderate PR and congenital/iatrogenic for severe PR. Mortality in patients with acquired ≥moderate PR appeared to be related to the underlying cause, with no excess mortality compared to matched patients without PR. Whether specifically severe PR confers excess mortality requires future investigation.