石墨烯
抗坏血酸
多巴胺
氧化物
碳纤维
电极
玻璃碳
纳米材料
化学
无机化学
材料科学
纳米技术
电化学
循环伏安法
有机化学
复合数
物理化学
神经科学
食品科学
复合材料
生物
作者
Wojciech Mazurkiewicz,Artur Małolepszy,Emilia Witkowska Nery
标识
DOI:10.1002/celc.202200330
摘要
Abstract The main hurdle in simultaneous analysis of dopamine and serotonin is not only their similar detection potential but also the polymerization of dopamine at physiological pH, which results in sensitivity loss. In this work, we investigated glassy carbon electrodes and electrodes modified with carbon black, graphene oxide, and carbon nanodots in terms of their ability to detect 5 neurobiologically relevant analytes (dopamine, serotonin, epinephrine, norepinephrine, and 3,4‐dihydroxyphenylacetic acid). We proved that simultaneous detection of dopamine and serotonin in the presence of uric and ascorbic acids is possible on electrodes modified with carbon black and graphene oxide, both in buffer solution and cell medium. Graphene oxide‐modified electrodes have shown the highest sensitivity towards all tested neurotransmitters. Moreover, a considerable shift of epinephrine, norepinephrine, and 3,4‐dihydroxyphenylacetic acid peaks towards more negative potentials was observed for electrodes modified with carbon black and graphene oxide as compared with glassy carbon electrodes. Electrodes covered with carbon nanodots were proven inappropriate due to their surface functionalization with ethylenediamine.
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