阿霉素
药理学
化学
医学
癌症研究
化疗
内科学
作者
Anna Maria Casazza,Giuseppina Savi,Graziella Pratesi,A. Di Marco
出处
期刊:European Journal of Cancer and Clinical Oncology
[Elsevier]
日期:1983-03-01
卷期号:19 (3): 411-418
被引量:25
标识
DOI:10.1016/0277-5379(83)90140-2
摘要
4'-Deoxydoxorubicin has been compared with doxorubicin as regards potency, antitumor activity and toxicity in tumored and non-tumored mice treated i.v. according to different schedules. 4'-Deoxydoxorubicin was 1.5-3 times more toxic and more potent than doxorubicin. At equitoxic doses, 4'-deoxydoxorubicin was: as active as doxorubicin against Gross leukemia, mammary carcinoma and MS-2 sarcoma; slightly less active than doxorubicin against B16 melanoma; more active than doxorubicin against colon 38 adenocarcinoma. The best schedule of administration of 4'-deoxydoxorubicin in mice was the weekly treatment. The strong effectiveness against colon 38 adenocarcinoma makes 4'-deoxydoxorubicin a particularly interesting new anthracycline derivative that deserves clinical trials.
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