Cystatin C,Kidney Function and Cardiovascular Disease

In clinical practice,the measurement of endogenous serum substances in order to estimate glomerular filtration rate(GFR) is commonly performed,and the serum creatinine level has become the most commonly used serum marker of renal function.However,the measurement of the serum creatinine concentration can sometimes lead to an overestimation of GFR.Most papers demonstrated the cystatin C production is constant.Only a few circumstances have been identified that have an impact on the serum cystatin C concentration,and serum cystatin C has been suggested to be a more sensitive and dependable marker.Moreover,data indicates that cystatin C plays an important role in treating cardiovascular disease.The present review proposes microinflammation as the unifying concept among cystatin C,kidney function and cardiovascular disease.