类风湿性关节炎
免疫抑制
单克隆抗体
甲氨蝶呤
医学
免疫学
单克隆
哮喘
泼尼松龙
靶向治疗
托珠单抗
细胞因子
疾病
抗体
内科学
癌症
作者
Joshua S. Davis,David Ferreira,Emma Paige,Craig Gedye,Michael Boyle
摘要
The past 2 decades have seen a revolution in our approach to therapeutic immunosuppression. We have moved from relying on broadly active traditional medications, such as prednisolone or methotrexate, toward more specific agents that often target a single receptor, cytokine, or cell type, using monoclonal antibodies, fusion proteins, or targeted small molecules. This change has transformed the treatment of many conditions, including rheumatoid arthritis, cancers, asthma, and inflammatory bowel disease, but along with the benefits have come risks.
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